Ontology highlight
ABSTRACT:
SUBMITTER: Chou HH
PROVIDER: S-EPMC3244271 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Chou Hsin-Hung HH Chiu Hsuan-Chao HC Delaney Nigel F NF Segrè Daniel D Marx Christopher J CJ
Science (New York, N.Y.) 20110601 6034
Epistasis has substantial impacts on evolution, in particular, the rate of adaptation. We generated combinations of beneficial mutations that arose in a lineage during rapid adaptation of a bacterium whose growth depended on a newly introduced metabolic pathway. The proportional selective benefit for three of the four loci consistently decreased when they were introduced onto more fit backgrounds. These three alleles all reduced morphological defects caused by expression of the foreign pathway. ...[more]