Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC3244383 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
PloS one 20111221 12
Drug repositioning helps fully explore indications for marketed drugs and clinical candidates. Here we show that the clinical side-effects (SEs) provide a human phenotypic profile for the drug, and this profile can suggest additional disease indications. We extracted 3,175 SE-disease relationships by combining the SE-drug relationships from drug labels and the drug-disease relationships from PharmGKB. Many relationships provide explicit repositioning hypotheses, such as drugs causing hypoglycemi ...[more]