Ontology highlight
ABSTRACT:
SUBMITTER: Marian C
PROVIDER: S-EPMC3244727 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Marian Christine C Huang Rong R Borch Richard F RF
Tetrahedron 20111201 52
Synthesis of a potential Src family SH2 domain inhibitor incorporating a 1,4-cis-enediol scaffold is reported. The synthetic route offers straightforward and highly selective access to the enediol and its associated chiral centers. Key steps include stereocontrolled syn-aldol coupling, amide alkynylation, and asymmetric ketone reduction. ...[more]