Ontology highlight
ABSTRACT:
SUBMITTER: Ugwu DI
PROVIDER: S-EPMC5602572 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Ugwu David Izuchukwu DI Okoro Uchechukwu Chris UC Ahmad Hilal H
PloS one 20170918 9
Sixteen new carboxamide derivatives bearing substituted benzenesulphonamide moiety (7a-p) were synthesized by boric acid mediated amidation of appropriate benzenesulphonamide with 2-amino-4-picoline and tested for anti-inflammatory activity. One compound 7c showed more potent anti-inflammatory activity than celecoxib at 3 h in carrageenan-induced rat paw edema bioassay. Compounds 7g and 7k also showed good anti-inflammatory activity comparable to celecoxib. Compound 7c appeared selectivity index ...[more]