Ontology highlight
ABSTRACT:
SUBMITTER: Maiso P
PROVIDER: S-EPMC3245208 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Maiso Patricia P Liu Yi Y Morgan Brittany B Azab Abdel Kareem AK Ren Pingda P Martin Michel B MB Zhang Yong Y Liu Yang Y Sacco Antonio A Ngo Hai H Azab Feda F Quang Phong P Rodig Scott J SJ Lin Charles P CP Roccaro Aldo M AM Rommel Christian C Ghobrial Irene M IM
Blood 20111101 26
Mammalian target of rapamycin (mTOR) is a downstream serine/threonine kinase of the PI3K/Akt pathway that integrates signals from the tumor microenvironment to regulate multiple cellular processes. Rapamycin and its analogs have not shown significant activity in multiple myeloma (MM), likely because of the lack of inhibition of TORC2. In the present study, we investigated the baseline activity of the PI3K/Akt/mTOR pathway TORC1/2 in MM cell lines with different genetic abnormalities. TORC1/2 kno ...[more]