Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC3245317 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Liu Yue Y Ye Fei F Yamada Kazunari K Tso Jonathan L JL Zhang Yibei Y Nguyen David H DH Dong Qinghua Q Soto Horacio H Choe Jinny J Dembo Anna A Wheeler Hayley H Eskin Ascia A Schmid Ingrid I Yong William H WH Mischel Paul S PS Cloughesy Timothy F TF Kornblum Harley I HI Nelson Stanley F SF Liau Linda M LM Tso Cho-Lea CL
Molecular cancer research : MCR 20111019 12
Glioblastoma stem cells (GSC) express both radial glial cell and neural crest cell (NCC)-associated genes. We report that endothelin 3 (EDN3), an essential mitogen for NCC development and migration, is highly produced by GSCs. Serum-induced proliferative differentiation rapidly decreased EDN3 production and downregulated the expression of stemness-associated genes, and reciprocally, two glioblastoma markers, EDN1 and YKL-40 transcripts, were induced. Correspondingly, patient glioblastoma tissues ...[more]