Ontology highlight
ABSTRACT:
SUBMITTER: Stephan AB
PROVIDER: S-EPMC3245797 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Stephan Aaron B AB Tobochnik Steven S Dibattista Michele M Wall Crystal M CM Reisert Johannes J Zhao Haiqing H
Nature neuroscience 20111106 1
Sensory perception requires accurate encoding of stimulus information by sensory receptor cells. We identified NCKX4, a potassium-dependent Na(+)/Ca(2+) exchanger, as being necessary for rapid response termination and proper adaptation of vertebrate olfactory sensory neurons (OSNs). Nckx4(-/-) (also known as Slc24a4) mouse OSNs displayed substantially prolonged responses and stronger adaptation. Single-cell electrophysiological analyses revealed that the majority of Na(+)-dependent Ca(2+) exchan ...[more]