Ontology highlight
ABSTRACT:
SUBMITTER: Claxton DP
PROVIDER: S-EPMC3245867 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Claxton Derek P DP Quick Matthias M Shi Lei L de Carvalho Fernanda Delmondes FD Weinstein Harel H Javitch Jonathan A JA McHaourab Hassane S HS
Nature structural & molecular biology 20100620 7
Crystallographic, computational and functional analyses of LeuT have revealed details of the molecular architecture of Na(+)-coupled transporters and the mechanistic nature of ion/substrate coupling, but the conformational changes that support a functional transport cycle have yet to be described fully. We have used site-directed spin labeling and electron paramagnetic resonance (EPR) analysis to capture the dynamics of LeuT in the region of the extracellular vestibule associated with the bindin ...[more]