Ontology highlight
ABSTRACT:
SUBMITTER: Kircher M
PROVIDER: S-EPMC3245947 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Kircher Martin M Sawyer Susanna S Meyer Matthias M
Nucleic acids research 20111021 1
Due to the increasing throughput of current DNA sequencing instruments, sample multiplexing is necessary for making economical use of available sequencing capacities. A widely used multiplexing strategy for the Illumina Genome Analyzer utilizes sample-specific indexes, which are embedded in one of the library adapters. However, this and similar multiplex approaches come with a risk of sample misidentification. By introducing indexes into both library adapters (double indexing), we have developed ...[more]