Ontology highlight
ABSTRACT:
SUBMITTER: Guerra AJ
PROVIDER: S-EPMC3246308 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Guerra Alfredo J AJ Dann Charles E CE Giedroc David P DP
Journal of the American Chemical Society 20111121 49
Streptococcus pneumoniae adhesin competence regulator (AdcR), the first metal-dependent member of the multiple antibiotic resistance regulator (MarR) family of proteins, represses the transcription of a high-affinity zinc-specific uptake transporter, a group of surface antigen zinc-binding pneumococcal histidine triad proteins (PhtA, PhtB, PhtD, and PhtE), and an AdcA homologue (AdcAII). The 2.0 Å resolution structure of Zn(II)-bound AdcR reveals a highly helical two-fold-symmetric dimer with tw ...[more]