Ontology highlight
ABSTRACT:
SUBMITTER: Giraudi PJ
PROVIDER: S-EPMC3246462 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Giraudi Pablo J PJ Bellarosa Cristina C Coda-Zabetta Carlos D CD Peruzzo Paolo P Tiribelli Claudio C
PloS one 20111227 12
We have previously reported that exposure of SH-SY5Y neuroblastoma cells to unconjugated bilirubin (UCB) resulted in a marked up-regulation of the mRNA encoding for the Na(+)-independent cystine∶glutamate exchanger System X(c)(-) (SLC7A11 and SLC3A2 genes). In this study we demonstrate that SH-SY5Y cells treated with UCB showed a higher cystine uptake due to a significant and specific increase in the activity of System X(c)(-), without the contribution of the others two cystine transporters (X(A ...[more]