Ontology highlight
ABSTRACT:
SUBMITTER: Calligaris R
PROVIDER: S-EPMC2789749 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Calligaris Raffaella R Bellarosa Cristina C Foti Rossana R Roncaglia Paola P Giraudi Pablo P Krmac Helena H Tiribelli Claudio C Gustincich Stefano S
BMC genomics 20091119
<h4>Background</h4>The deposition of unconjugated bilirubin (UCB) in selected regions of the brain results in irreversible neuronal damage, or Bilirubin Encephalopathy (BE). Although UCB impairs a large number of cellular functions in other tissues, the basic mechanisms of neurotoxicity have not yet been fully clarified. While cells can accumulate UCB by passive diffusion, cell protection may involve multiple mechanisms including the extrusion of the pigment as well as pro-survival homeostatic r ...[more]