Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC3247072 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Li Lin L Turatti Fabio F Crow Desiree D Bading James R JR Anderson Anne-Line AL Poku Erasmus E Yazaki Paul J PJ Williams Lawrence E LE Tamvakis Debra D Sanders Paul P Leong David D Raubitschek Andrew A Hudson Peter J PJ Colcher David D Shively John E JE
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100616 7
<h4>Unlabelled</h4>Diabodies are noncovalent dimers of single-chain antibody fragments that retain the avidity of intact IgG but have more favorable blood clearance than intact IgG. Radiometals offer a wide range of half-lives and emissions for matching imaging and therapy requirements and provide facile labeling of chelate-antibody conjugates. However, because of their high retention and metabolism in the kidney, the use of radiometal-labeled diabodies can be problematic for both imaging and th ...[more]