Ontology highlight
ABSTRACT:
SUBMITTER: Srideshikan SM
PROVIDER: S-EPMC6911626 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Srideshikan Sargur Madabushi SM Brooks Jamison J Zuro Darren D Kumar Bijender B Sanchez James J Echavarria Parra Liliana L Orellana Marvin M Vishwasrao Paresh P Nair Indu I Chea Junie J Poku Kofi K Bowles Nicole N Miller Aaron A Ebner Todd T Molnar Justin J Rosenthal Joseph J Vallera Daniel A DA Wong Jeffrey Y C JYC Stein Anthony S AS Colcher David D Shively John E JE Yazaki Paul J PJ Hui Susanta K SK
Clinical cancer research : an official journal of the American Association for Cancer Research 20190923 24
<h4>Purpose</h4>Acute myeloid leukemia (AML) is a highly aggressive form of leukemia, which results in poor survival outcomes. Currently, diagnosis and prognosis are based on invasive single-point bone marrow biopsies (iliac crest). There is currently no AML-specific noninvasive imaging method to detect disease, including in extramedullary organs, representing an unmet clinical need. About 85% to 90% of human myeloid leukemia cells express CD33 cell surface receptors, highlighting CD33 as an ide ...[more]