Ontology highlight
ABSTRACT:
SUBMITTER: Luo H
PROVIDER: S-EPMC3247986 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Luo Hongyu H Wu Zenghui Z Qi Shijie S Jin Wei W Han Bing B Wu Jiangping J
The Journal of biological chemistry 20111108 52
IL-7 plays vital roles in thymocyte development, T cell homeostasis, and the survival of these cells. IL-7 receptor α (IL-7Rα) on thymocytes and T cells is rapidly internalized upon IL-7 ligation. Ephrins (Efns) are cell surface molecules and ligands of the largest receptor kinase family, Eph kinases. We discovered that T cell-specific double gene knock-out (dKO) of Efnb1 and Efnb2 in mice led to reduced IL-7Rα expression in thymocytes and T cells, and that IL-7Rα down-regulation was accelerated ...[more]