Ontology highlight
ABSTRACT:
SUBMITTER: Sivak JM
PROVIDER: S-EPMC3248015 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Sivak Jeremy M JM Ostriker Allison C AC Woolfenden Amber A Demirs John J Cepeda Rosemarie R Long Debby D Anderson Karen K Jaffee Bruce B
The Journal of biological chemistry 20111109 52
Pathological neovascularization occurs when a balance of pro- and anti-angiogenic factors is disrupted, accompanied by an amplifying inflammatory cascade. However, the interdependence of these responses and the mechanism triggering the initial angiogenic switch have remained unclear. We present data from an epithelial debridement model of corneal neovascularization describing an initial 3-day period when a substantial component of neovascular growth occurs. Administration of selective inhibitors ...[more]