Ontology highlight
ABSTRACT:
SUBMITTER: Zachman AL
PROVIDER: S-EPMC4164579 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Zachman Angela L AL Wang Xintong X Tucker-Schwartz Jason M JM Fitzpatrick Sean T ST Lee Sue H SH Guelcher Scott A SA Skala Melissa C MC Sung Hak-Joon HJ
Biomaterials 20140822 36
Peripheral artery disease (PAD) is characterized by vessel occlusion and ischemia in the limbs. Treatment for PAD with surgical interventions has been showing limited success. Moreover, recent clinical trials with treatment of angiogenic growth factors proved ineffective as increased angiogenesis triggered severe inflammation in a proportionally coupled fashion. Hence, the overarching goal of this research was to address this issue by developing a biomaterial system that enables controlled, dual ...[more]