Ontology highlight
ABSTRACT:
SUBMITTER: Frahm N
PROVIDER: S-EPMC3248307 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Frahm Nicole N DeCamp Allan C AC Friedrich David P DP Carter Donald K DK Defawe Olivier D OD Kublin James G JG Casimiro Danilo R DR Duerr Ann A Robertson Michael N MN Buchbinder Susan P SP Huang Yunda Y Spies Gregory A GA De Rosa Stephen C SC McElrath M Juliana MJ
The Journal of clinical investigation 20111227 1
Recombinant viruses hold promise as vectors for vaccines to prevent infectious diseases with significant global health impacts. One of their major limitations is that preexisting anti-vector neutralizing antibodies can reduce T cell responses to the insert antigens; however, the impact of vector-specific cellular immunity on subsequent insert-specific T cell responses has not been assessed in humans. Here, we have identified and compared adenovirus-specific and HIV-specific T cell responses in s ...[more]