Ontology highlight
ABSTRACT:
SUBMITTER: Boppana S
PROVIDER: S-EPMC6782105 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20191001 10
HLA-I-associated human immunodeficiency virus (HIV) adaptation is known to negatively affect disease progression and CD8 T-cell responses. We aimed to assess how HLA-I-associated adaptation affects HIV vaccine-induced CD8 T-cell responses in 2 past vaccine efficacy trials. We found that vaccine-encoded adapted epitopes were less immunogenic than vaccine-encoded nonadapted epitopes, and adapted epitope-specific responses were less polyfunctional than nonadapted epitope-specific responses. Along t ...[more]