Ontology highlight
ABSTRACT:
SUBMITTER: Aubert RD
PROVIDER: S-EPMC3248546 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Aubert Rachael D RD Kamphorst Alice O AO Sarkar Surojit S Vezys Vaiva V Ha Sang-Jun SJ Barber Daniel L DL Ye Lilin L Sharpe Arlene H AH Freeman Gordon J GJ Ahmed Rafi R
Proceedings of the National Academy of Sciences of the United States of America 20111212 52
CD4 T cells play a critical role in regulating CD8 T-cell responses during chronic viral infection. Several studies in animal models and humans have shown that the absence of CD4 T-cell help results in severe dysfunction of virus-specific CD8 T cells. However, whether function can be restored in already exhausted CD8 T cells by providing CD4 T-cell help at a later time remains unexplored. In this study, we used a mouse model of chronic lymphocytic choriomeningitis virus (LCMV) infection to addre ...[more]