Ontology highlight
ABSTRACT:
SUBMITTER: Zhan W
PROVIDER: S-EPMC3248799 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Zhan Weiqiang W Jiang Yi Y Sharma Shubhada S Brodie Peggy J PJ Bane Susan S Kingston David G I DG Liotta Dennis C DC Snyder James P JP
Chemistry (Weinheim an der Bergstrasse, Germany) 20111130 52
A series of conformationally restrained epothilone analogues with a short bridge between the methyl groups at C6 and C8 was designed to mimic the binding pose assigned to our recently reported EpoA-microtubule binding model. A versatile synthetic route to these bridged epothilone analogues has been successfully devised and implemented. Biological evaluation of the compounds against A2780 human ovarian cancer and PC3 prostate cancer cell lines suggested that the introduction of a bridge between C ...[more]