Ontology highlight
ABSTRACT:
SUBMITTER: Zhan W
PROVIDER: S-EPMC3249659 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Organic letters 20080321 8
A conformationally restrained epothilone A analogue (3) with a short bridge between methyl groups at C6 and C8 was designed and synthesized. Preliminary biological evaluation indicates 3 to be only weakly active (IC50 = 8.5 microM) against the A2780 human ovarian cancer cell line. ...[more]