Ontology highlight
ABSTRACT:
SUBMITTER: Smith ER
PROVIDER: S-EPMC3249835 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Smith Edwin R ER Lin Chengqi C Garrett Alexander S AS Thornton Janet J Mohaghegh Nima N Hu Deqing D Jackson Jessica J Saraf Anita A Swanson Selene K SK Seidel Christopher C Florens Laurence L Washburn Michael P MP Eissenberg Joel C JC Shilatifard Ali A
Molecular cell 20111201 6
Eleven-nineteen lysine-rich leukemia (ELL) participates in the super elongation complex (SEC) with the RNA polymerase II (Pol II) CTD kinase P-TEFb. SEC is a key regulator in the expression of HOX genes in mixed lineage leukemia (MLL)-based hematological malignancies, in the control of induced gene expression early in development, and in immediate early gene transcription. Here, we identify an SEC-like complex in Drosophila, as well as a distinct ELL-containing complex that lacks P-TEFb and othe ...[more]