Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi H
PROVIDER: S-EPMC7044329 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Takahashi Hidehisa H Ranjan Amol A Chen Shiyuan S Suzuki Hidefumi H Shibata Mio M Hirose Tomonori T Hirose Hiroko H Sasaki Kazunori K Abe Ryota R Chen Kai K He Yanfeng Y Zhang Ying Y Takigawa Ichigaku I Tsukiyama Tadasuke T Watanabe Masashi M Fujii Satoshi S Iida Midori M Yamamoto Junichi J Yamaguchi Yuki Y Suzuki Yutaka Y Matsumoto Masaki M Nakayama Keiichi I KI Washburn Michael P MP Saraf Anita A Florens Laurence L Sato Shigeo S Tomomori-Sato Chieri C Conaway Ronald C RC Conaway Joan W JW Hatakeyama Shigetsugu S
Nature communications 20200226 1
Mediator is a coregulatory complex that regulates transcription of Pol II-dependent genes. Previously, we showed that human Mediator subunit MED26 plays a role in the recruitment of Super Elongation Complex (SEC) or Little Elongation Complex (LEC) to regulate the expression of certain genes. MED26 plays a role in recruiting SEC to protein-coding genes including c-myc and LEC to small nuclear RNA (snRNA) genes. However, how MED26 engages SEC or LEC to regulate distinct genes is unclear. Here, we ...[more]