Ontology highlight
ABSTRACT:
SUBMITTER: Malik AF
PROVIDER: S-EPMC3250158 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Malik Ahsan F AF Hoque Rafaz R Ouyang Xinshou X Ghani Ayaz A Hong Enping E Khan Khadija K Moore Laura Beth LB Ng Gilbert G Munro Fay F Flavell Richard A RA Shi Yan Y Kyriakides Themis R TR Mehal Wajahat Z WZ
Proceedings of the National Academy of Sciences of the United States of America 20111122 50
Implantation of biomaterials and devices into soft tissues leads to the development of the foreign body response (FBR), which can interfere with implant function and eventually lead to failure. The FBR consists of overlapping acute and persistent inflammatory phases coupled with collagenous encapsulation and currently there are no therapeutic options. Initiation of the FBR involves macrophage activation, proceeding to giant cell formation, fibroblast activation, and collagen matrix deposition. D ...[more]