Ontology highlight
ABSTRACT:
SUBMITTER: Christo SN
PROVIDER: S-EPMC4748295 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20160210
Detailing the inflammatory mechanisms of biomaterial-implant induced foreign body responses (FBR) has implications for revealing targetable pathways that may reduce leukocyte activation and fibrotic encapsulation of the implant. We have adapted a model of poly(methylmethacrylate) (PMMA) bead injection to perform an assessment of the mechanistic role of the ASC-dependent inflammasome in this process. We first demonstrate that ASC(-/-) mice subjected to PMMA bead injections had reduced cell infilt ...[more]