Defining human ERAD networks through an integrative mapping strategy.
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ABSTRACT:
SUBMITTER: Christianson JC
PROVIDER: S-EPMC3250479 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Publications
Defining human ERAD networks through an integrative mapping strategy.
Christianson John C JC Olzmann James A JA Shaler Thomas A TA Sowa Mathew E ME Bennett Eric J EJ Richter Caleb M CM Tyler Ryan E RE Greenblatt Ethan J EJ Harper J Wade JW Kopito Ron R RR
Nature cell biology 20111127 1
Proteins that fail to correctly fold or assemble into oligomeric complexes in the endoplasmic reticulum (ER) are degraded by a ubiquitin- and proteasome-dependent process known as ER-associated degradation (ERAD). Although many individual components of the ERAD system have been identified, how these proteins are organized into a functional network that coordinates recognition, ubiquitylation and dislocation of substrates across the ER membrane is not well understood. We have investigated the fun ...[more]
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