Ontology highlight
ABSTRACT:
SUBMITTER: Coufal NG
PROVIDER: S-EPMC3251057 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Coufal Nicole G NG Garcia-Perez Josè Luis JL Peng Grace E GE Marchetto Maria C N MC Muotri Alysson R AR Mu Yangling Y Carson Christian T CT Macia Angela A Moran John V JV Gage Fred H FH
Proceedings of the National Academy of Sciences of the United States of America 20111209 51
Long interspersed element-1 (L1) retrotransposons compose ∼20% of the mammalian genome, and ongoing L1 retrotransposition events can impact genetic diversity by various mechanisms. Previous studies have demonstrated that endogenous L1 retrotransposition can occur in the germ line and during early embryonic development. In addition, recent data indicate that engineered human L1s can undergo somatic retrotransposition in human neural progenitor cells and that an increase in human-specific L1 DNA c ...[more]