Ontology highlight
ABSTRACT:
SUBMITTER: Ferrer IR
PROVIDER: S-EPMC3251074 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Ferrer Ivana R IR Wagener Maylene E ME Song Minqing M Kirk Allan D AD Larsen Christian P CP Ford Mandy L ML
Proceedings of the National Academy of Sciences of the United States of America 20111205 51
Blockade of the CD40/CD154 pathway potently attenuates T-cell responses in models of autoimmunity, inflammation, and transplantation. Indeed, CD40 pathway blockade remains one of the most powerful methods of prolonging graft survival in models of transplantation. But despite this effectiveness, the cellular and molecular mechanisms underlying the protective effects of CD40 pathway blockade are incompletely understood. Furthermore, the relative contributions of deletion, anergy, and regulation ha ...[more]