Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC3251230 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Zhang Yingfan Y Conti Mary Anne MA Malide Daniela D Dong Fan F Wang Aibing A Shmist Yelena A YA Liu Chengyu C Zerfas Patricia P Daniels Mathew P MP Chan Chi-Chao CC Kozin Elliot E Kachar Bechara B Kelley Michael J MJ Kopp Jeffrey B JB Adelstein Robert S RS
Blood 20110908 1
We have generated 3 mouse lines, each with a different mutation in the nonmuscle myosin II-A gene, Myh9 (R702C, D1424N, and E1841K). Each line develops MYH9-related disease similar to that found in human patients. R702C mutant human cDNA fused with green fluorescent protein was introduced into the first coding exon of Myh9, and D1424N and E1841K mutations were introduced directly into the corresponding exons. Homozygous R702C mice die at embryonic day 10.5-11.5, whereas homozygous D1424N and E18 ...[more]