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Origins of disparities in cardiovascular disease: birth weight, body mass index, and young adult systolic blood pressure in the national longitudinal study of adolescent health.

ABSTRACT: We evaluated the contributions of birth weight and current body mass index (BMI) to racial/ethnic disparities in systolic blood pressure (SBP) in the United States.Participants were 10,046 young adults (ages 24-32) in the National Longitudinal Study of Adolescent Health. SBP, BMI, and other contemporaneous factors were assessed at Wave IV (2007-2008); birth weight and other early life factors were reported at Wave I (1994-1995). Data were analyzed using sex- and race-stratified multivariable regression models.Racial/ethnic disparities in SBP were limited to black and white females. The black-white female disparity in SBP was 3.36 mmHg and was partially explained by current BMI, but not birth weight. Associations between birth weight and SBP were limited to males, in whom we found a decrease of 1.05 mmHg in SBP per 1-kg increase in birth weight (95% confidence interval, -1.90, -0.20). This inverse relationship strengthened after adjusting for BMI and other factors, and was strongest among black and white males. A significant association between BMI and SBP was found in all racial/ethnic and sex subgroups.In this U.S. national cohort, birth weight is negatively associated with SBP among black and white young adult males.

SUBMITTER: Richardson LJ

PROVIDER: S-EPMC3251513 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Origins of disparities in cardiovascular disease: birth weight, body mass index, and young adult systolic blood pressure in the national longitudinal study of adolescent health.

Richardson Liana J LJ Hussey Jon M JM Strutz Kelly L KL

Annals of epidemiology 20110416 8

<h4>Purpose</h4>We evaluated the contributions of birth weight and current body mass index (BMI) to racial/ethnic disparities in systolic blood pressure (SBP) in the United States.<h4>Methods</h4>Participants were 10,046 young adults (ages 24-32) in the National Longitudinal Study of Adolescent Health. SBP, BMI, and other contemporaneous factors were assessed at Wave IV (2007-2008); birth weight and other early life factors were reported at Wave I (1994-1995). Data were analyzed using sex- and r ...[more]

PMID: 21497518

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Project description:ImportanceCancer diagnosis and treatment may adversely affect reproductive outcomes among female cancer survivors.ObjectiveTo compare the birth outcomes of adolescent and young adult cancer survivors (AYA [diagnosed at ages 15-39 years]) with those of women without a cancer diagnosis.Design, setting, and participantsThe North Carolina Central Cancer Registry (CCR) was used to identify female AYA cancer survivors diagnosed from January 2000 to December 2013; CCR records were linked to statewide birth certificate files from January 2000 to December 2014 to identify postdiagnosis live births to AYA survivors (n = 2598). A comparison cohort of births to women without a recorded cancer diagnosis was randomly selected from birth certificate files (n = 12 990) with frequency matching on maternal age and year of delivery.Main outcomes and measuresPrevalence of preterm birth, low birth weight, small-for-gestational-age births, cesarean delivery, and low Apgar score.ResultsOverall, 2598 births to AYA cancer survivors (mean [SD] maternal age, 31 [5] years) were included. Births to AYA cancer survivors had a significantly increased prevalence of preterm birth (prevalence ratio [PR], 1.52; 95% CI, 1.34-1.71), low birth weight (PR, 1.59; 95% CI, 1.38-1.83), and cesarean delivery (PR, 1.08; 95% CI, 1.01-1.14) relative to the comparison cohort of 1299. The higher prevalence of these outcomes was most concentrated among births to women diagnosed during pregnancy. Other factors associated with preterm birth and low birth weight included treatment with chemotherapy and a diagnosis of breast cancer, non-Hodgkin lymphoma, or gynecologic cancers. The prevalence of small-for-gestational-age births and low Apgar score (<7) did not differ significantly between groups.Conclusions and relevanceLive births to AYA cancer survivors may have an increased risk of preterm birth and low birth weight, suggesting that additional surveillance of pregnancies in this population is warranted. Our findings may inform the reproductive counseling of female AYA cancer survivors.

Dataset Information

Origins of disparities in cardiovascular disease: birth weight, body mass index, and young adult systolic blood pressure in the national longitudinal study of adolescent health.

Publications

Origins of disparities in cardiovascular disease: birth weight, body mass index, and young adult systolic blood pressure in the national longitudinal study of adolescent health.

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