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Role of Vascular Adaptation in Determining Systolic Blood Pressure in Young Adults.


ABSTRACT: Background Two individuals can have a similar pulse pressure (PP) but different levels of systolic blood pressure (SBP), although the underlying mechanisms have not been described. We hypothesized that, for a given level of PP, differences in SBP relate to peripheral vascular resistance (PVR); and we tested this hypothesis in a large cohort of healthy young adults. Methods and Results Demographic, biochemical, and hemodynamic data from 3103 subjects were available for the current analyses. In both men and women, for a given level of PP, higher SBP was associated with significantly higher body weight, body mass index, heart rate, and PVR (P<0.05 versus those with lower BP for all comparisons). Moreover, stratifying individuals by quartiles of PP and PVR revealed a stepwise increase in SBP from the lowest to highest quartile for each variable, with the highest SBP occurring in those in the highest quartile of both PP and PVR (P<0.001 for overall trend for both sexes). PVR was also increased with increasing tertile of minimum forearm vascular resistance, in both men (P=0.002) and women (P=0.03). Conclusions Increased PVR, mediated in part through altered resistance vessel structure, strongly associates with the elevation of SBP for a given level of PP in young adults. An impaired ability to adapt PVR appropriately to a given level of PP may be an important mechanism underlying elevated SBP in young adults.

SUBMITTER: Yu S 

PROVIDER: S-EPMC7428627 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Role of Vascular Adaptation in Determining Systolic Blood Pressure in Young Adults.

Yu Shikai S   Middlemiss Jessica E JE   Nardin Chiara C   Hickson Stacey S SS   Miles Karen L KL   Yasmin   Maki-Petaja Kaisa M KM   McDonnell Barry J BJ   Cockcroft John R JR   Wilkinson Ian B IB   McEniery Carmel M CM  

Journal of the American Heart Association 20200330 7


Background Two individuals can have a similar pulse pressure (PP) but different levels of systolic blood pressure (SBP), although the underlying mechanisms have not been described. We hypothesized that, for a given level of PP, differences in SBP relate to peripheral vascular resistance (PVR); and we tested this hypothesis in a large cohort of healthy young adults. Methods and Results Demographic, biochemical, and hemodynamic data from 3103 subjects were available for the current analyses. In bo  ...[more]

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