A genome-wide association search for type 2 diabetes genes in African Americans.
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ABSTRACT:
SUBMITTER: Palmer ND
PROVIDER: S-EPMC3251563 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
A genome-wide association search for type 2 diabetes genes in African Americans.
Palmer Nicholette D ND McDonough Caitrin W CW Hicks Pamela J PJ Roh Bong H BH Wing Maria R MR An S Sandy SS Hester Jessica M JM Cooke Jessica N JN Bostrom Meredith A MA Rudock Megan E ME Talbert Matthew E ME Lewis Joshua P JP Ferrara Assiamira A Lu Lingyi L Ziegler Julie T JT Sale Michele M MM Divers Jasmin J Shriner Daniel D Adeyemo Adebowale A Rotimi Charles N CN Ng Maggie C Y MC Langefeld Carl D CD Freedman Barry I BI Bowden Donald W DW Voight Benjamin F BF Scott Laura J LJ Steinthorsdottir Valgerdur V Morris Andrew P AP Dina Christian C Welch Ryan P RP Zeggini Eleftheria E Huth Cornelia C Aulchenko Yurii S YS Thorleifsson Gudmar G McCulloch Laura J LJ Ferreira Teresa T Grallert Harald H Amin Najaf N Wu Guanming G Willer Cristen J CJ Raychaudhuri Soumya S McCarroll Steve A SA Langenberg Claudia C Hofmann Oliver M OM Dupuis Josée J Qi Lu L Segrè Ayellet V AV van Hoek Mandy M Navarro Pau P Ardlie Kristin K Balkau Beverley B Benediktsson Rafn R Bennett Amanda J AJ Blagieva Roza R Boerwinkle Eric E Bonnycastle Lori L LL Boström Kristina Bengtsson KB Bravenboer Bert B Bumpstead Suzannah S Burtt Noël P NP Charpentier Guillaume G Chines Peter S PS Cornelis Marilyn M Couper David J DJ Crawford Gabe G Doney Alex S F AS Elliott Katherine S KS Elliott Amanda L AL Erdos Michael R MR Fox Caroline S CS Franklin Christopher S CS Ganser Martha M Gieger Christian C Grarup Niels N Green Todd T Griffin Simon S Groves Christopher J CJ Guiducci Candace C Hadjadj Samy S Hassanali Neelam N Herder Christian C Isomaa Bo B Jackson Anne U AU Johnson Paul R V PR Jørgensen Torben T Kao Wen H L WH Klopp Norman N Kong Augustine A Kraft Peter P Kuusisto Johanna J Lauritzen Torsten T Li Man M Lieverse Aloysius A Lindgren Cecilia M CM Lyssenko Valeriya V Marre Michel M Meitinger Thomas T Midthjell Kristian K Morken Mario A MA Narisu Narisu N Nilsson Peter P Owen Katharine R KR Payne Felicity F Perry John R B JR Petersen Ann-Kristin AK Platou Carl C Proença Christine C Prokopenko Inga I Rathmann Wolfgang W Rayner N William NW Robertson Neil R NR Rocheleau Ghislain G Roden Michael M Sampson Michael J MJ Saxena Richa R Shields Beverley M BM Shrader Peter P Sigurdsson Gunnar G Sparsø Thomas T Strassburger Klaus K Stringham Heather M HM Sun Qi Q Swift Amy J AJ Thorand Barbara B Tichet Jean J Tuomi Tiinamaija T van Dam Rob M RM van Haeften Timon W TW van Herpt Thijs T van Vliet-Ostaptchouk Jana V JV Walters G Bragi GB Weedon Michael N MN Wijmenga Cisca C Witteman Jacqueline J Bergman Richard N RN Cauchi Stephane S Collins Francis S FS Gloyn Anna L AL Gyllensten Ulf U Hansen Torben T Hide Winston A WA Hitman Graham A GA Hofman Albert A Hunter David J DJ Hveem Kristian K Laakso Markku M Mohlke Karen L KL Morris Andrew D AD Palmer Colin N A CN Pramstaller Peter P PP Rudan Igor I Sijbrands Eric E Stein Lincoln D LD Tuomilehto Jaakko J Uitterlinden Andre A Walker Mark M Wareham Nicholas J NJ Watanabe Richard M RM Abecasis Goncalo R GR Boehm Bernhard O BO Campbell Harry H Daly Mark J MJ Hattersley Andrew T AT Hu Frank B FB Meigs James B JB Pankow James S JS Pedersen Oluf O Wichmann H-Erich HE Barroso Inês I Florez Jose C JC Frayling Timothy M TM Groop Leif L Sladek Rob R Thorsteinsdottir Unnur U Wilson James F JF Illig Thomas T Froguel Philippe P van Duijn Cornelia M CM Stefansson Kari K Altshuler David D Boehnke Michael M McCarthy Mark I MI Soranzo Nicole N Wheeler Eleanor E Glazer Nicole L NL Bouatia-Naji Nabila N Mägi Reedik R Randall Joshua J Johnson Toby T Elliott Paul P Rybin Denis D Henneman Peter P Dehghan Abbas A Hottenga Jouke Jan JJ Song Kijoung K Goel Anuj A Egan Josephine M JM Lajunen Taina T Doney Alex A Kanoni Stavroula S Cavalcanti-Proença Christine C Kumari Meena M Timpson Nicholas J NJ Zabena Carina C Ingelsson Erik E An Ping P O'Connell Jeffrey J Luan Jian'an J Elliott Amanda A McCarroll Steven A SA Roccasecca Rosa Maria RM Pattou François F Sethupathy Praveen P Ariyurek Yavuz Y Barter Philip P Beilby John P JP Ben-Shlomo Yoav Y Bergmann Sven S Bochud Murielle M Bonnefond Amélie A Borch-Johnsen Knut K Böttcher Yvonne Y Brunner Eric E Bumpstead Suzannah J SJ Chen Yii-Der Ida YD Chines Peter P Clarke Robert R Coin Lachlan J M LJ Cooper Matthew N MN Crisponi Laura L Day Ian N M IN de Geus Eco J C EJ Delplanque Jerome J Fedson Annette C AC Fischer-Rosinsky Antje A Forouhi Nita G NG Frants Rune R Franzosi Maria Grazia MG Galan Pilar P Goodarzi Mark O MO Graessler Jürgen J Grundy Scott S Gwilliam Rhian R Hallmans Göran G Hammond Naomi N Han Xijing X Hartikainen Anna-Liisa AL Hayward Caroline C Heath Simon C SC Hercberg Serge S Hicks Andrew A AA Hillman David R DR Hingorani Aroon D AD Hui Jennie J Hung Joe J Jula Antti A Kaakinen Marika M Kaprio Jaakko J Kesaniemi Y Antero YA Kivimaki Mika M Knight Beatrice B Koskinen Seppo S Kovacs Peter P Kyvik Kirsten Ohm KO Lathrop G Mark GM Lawlor Debbie A DA Le Bacquer Olivier O Lecoeur Cécile C Li Yun Y Mahley Robert R Mangino Massimo M Manning Alisa K AK Martínez-Larrad María Teresa MT McAteer Jarred B JB McPherson Ruth R Meisinger Christa C Melzer David D Meyre David D Mitchell Braxton D BD Mukherjee Sutapa S Naitza Silvia S Neville Matthew J MJ Oostra Ben A BA Orrù Marco M Pakyz Ruth R Paolisso Giuseppe G Pattaro Cristian C Pearson Daniel D Peden John F JF Pedersen Nancy L NL Perola Markus M Pfeiffer Andreas F H AF Pichler Irene I Polasek Ozren O Posthuma Danielle D Potter Simon C SC Pouta Anneli A Province Michael A MA Psaty Bruce M BM Rayner Nigel W NW Rice Kenneth K Ripatti Samuli S Rivadeneira Fernando F Rolandsson Olov O Sandbaek Annelli A Sandhu Manjinder M Sanna Serena S Sayer Avan Aihie AA Scheet Paul P Seedorf Udo U Sharp Stephen J SJ Shields Beverley B Sijbrands Eric J G EJ Silveira Angela A Simpson Laila L Singleton Andrew A Smith Nicholas L NL Sovio Ulla U Swift Amy A Syddall Holly H Syvänen Ann-Christine AC Tanaka Toshiko T Tönjes Anke A Uitterlinden André G AG van Dijk Ko Willems KW Varma Dhiraj D Visvikis-Siest Sophie S Vitart Veronique V Vogelzangs Nicole N Waeber Gérard G Wagner Peter J PJ Walley Andrew A Ward Kim L KL Watkins Hugh H Wild Sarah H SH Willemsen Gonneke G Willemsen Gonneke G Witteman Jaqueline C M JC Yarnell John W G JW Zelenika Diana D Zethelius Björn B Zhai Guangju G Zhao Jing Hua JH Zillikens M Carola MC Borecki Ingrid B IB Loos Ruth J F RJ Meneton Pierre P Magnusson Patrik K E PK Nathan David M DM Williams Gordon H GH Silander Kaisa K Salomaa Veikko V Smith George Davey GD Bornstein Stefan R SR Schwarz Peter P Spranger Joachim J Karpe Fredrik F Shuldiner Alan R AR Cooper Cyrus C Dedoussis George V GV Serrano-Ríos Manuel M Lind Lars L Palmer Lyle J LJ Franks Paul W PW Ebrahim Shah S Marmot Michael M Kao W H Linda WH Pramstaller Peter Paul PP Wright Alan F AF Stumvoll Michael M Hamsten Anders A Buchanan Thomas A TA Valle Timo T TT Rotter Jerome I JI Siscovick David S DS Penninx Brenda W J H BW Boomsma Dorret I DI Deloukas Panos P Spector Timothy D TD Ferrucci Luigi L Cao Antonio A Scuteri Angelo A Schlessinger David D Uda Manuela M Ruokonen Aimo A Jarvelin Marjo-Riitta MR Waterworth Dawn M DM Vollenweider Peter P Peltonen Leena L Mooser Vincent V Sladek Robert R
PloS one 20120104 1
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n ...[more]
