Ontology highlight
ABSTRACT:
SUBMITTER: Sordillo JE
PROVIDER: S-EPMC3252252 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Sordillo Joanne E JE Sharma Sunita S Poon Audrey A Lasky-Su Jessica J Belanger Kathleen K Milton Donald K DK Bracken Michael B MB Triche Elizabeth W EW Leaderer Brian P BP Gold Diane R DR Litonjua Augusto A AA
BMC medical genetics 20111208
<h4>Background</h4>Polymorphisms in the endotoxin-mediated TLR4 pathway genes have been associated with asthma and atopy. We aimed to examine how genetic polymorphisms in innate immunity pathways interact with endotoxin to influence asthma risk in children.<h4>Methods</h4>In a previous analysis of 372 children from the Boston Home Allergens and the Connecticut Childhood Asthma studies, 7 SNPs in 6 genes (CARD15, TGFB1, LY96, ACAA1, DEFB1 and IFNG) involved in innate immune pathways were associat ...[more]