Ontology highlight
ABSTRACT:
SUBMITTER: Adiwijaya BS
PROVIDER: S-EPMC3252270 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Adiwijaya Bambang S BS Kieffer Tara L TL Henshaw Joshua J Eisenhauer Karen K Kimko Holly H Alam John J JJ Kauffman Robert S RS Garg Varun V
PLoS computational biology 20120105 1
We propose an integrative, mechanistic model that integrates in vitro virology data, pharmacokinetics, and viral response to a combination regimen of a direct-acting antiviral (telaprevir, an HCV NS3-4A protease inhibitor) and peginterferon alfa-2a/ribavirin (PR) in patients with genotype 1 chronic hepatitis C (CHC). This model, which was parameterized with on-treatment data from early phase clinical studies in treatment-naïve patients, prospectively predicted sustained virologic response (SVR) ...[more]