Ontology highlight
ABSTRACT:
SUBMITTER: Vaira V
PROVIDER: S-EPMC3252463 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Vaira V V Faversani A A Dohi T T Montorsi M M Augello C C Gatti S S Coggi G G Altieri D C DC Bosari S S
Oncogene 20110606 1
The expression of small, non-coding RNA or microRNAs (miR), is frequently deregulated in human cancer, but how these pathways affect disease progression is still largely elusive. Here, we report on a miR, miR-296, which is progressively lost during tumor progression and correlates with metastatic disease in colorectal, breast, lung, gastric, parathyroid, liver and bile ducts cancers. Functionally, miR-296 controls a global cell motility gene signature in epithelial cells by transcriptionally rep ...[more]