Ontology highlight
ABSTRACT:
SUBMITTER: Deuquet J
PROVIDER: S-EPMC3252584 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Deuquet Julie J Lausch Ekkehart E Superti-Furga Andrea A van der Goot F Gisou FG
The EMBO journal 20111206 1
Capillary morphogenesis gene 2 (CMG2) is a type I membrane protein involved in the homeostasis of the extracellular matrix. While it shares interesting similarities with integrins, its exact molecular role is unknown. The interest and knowledge about CMG2 largely stems from the fact that it is involved in two diseases, one infectious and one genetic. CMG2 is the main receptor of the anthrax toxin, and knocking out this gene in mice renders them insensitive to infection with Bacillus anthracis sp ...[more]