Ontology highlight
ABSTRACT:
SUBMITTER: Wray NR
PROVIDER: S-EPMC3252611 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Wray N R NR Pergadia M L ML Blackwood D H R DH Penninx B W J H BW Gordon S D SD Nyholt D R DR Ripke S S MacIntyre D J DJ McGhee K A KA Maclean A W AW Smit J H JH Hottenga J J JJ Willemsen G G Middeldorp C M CM de Geus E J C EJ Lewis C M CM McGuffin P P Hickie I B IB van den Oord E J C G EJ Liu J Z JZ Macgregor S S McEvoy B P BP Byrne E M EM Medland S E SE Statham D J DJ Henders A K AK Heath A C AC Montgomery G W GW Martin N G NG Boomsma D I DI Madden P A F PA Sullivan P F PF
Molecular psychiatry 20101102 1
Major depressive disorder (MDD) is a common complex disorder with a partly genetic etiology. We conducted a genome-wide association study of the MDD2000+ sample (2431 cases, 3673 screened controls and >1 M imputed single-nucleotide polymorphisms (SNPs)). No SNPs achieved genome-wide significance either in the MDD2000+ study, or in meta-analysis with two other studies totaling 5763 cases and 6901 controls. These results imply that common variants of intermediate or large effect do not have main e ...[more]