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Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.

ABSTRACT: Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown. Here we show that highly dynamic hepatocyte actin reorganization events occur around developing Plasmodium berghei parasites inside human hepatoma cells. Actin reorganization is most prominent between 10 to 16 hours post infection and depends on the actin severing and capping protein, gelsolin. Live cell imaging studies also suggest that the hepatocyte cytoskeleton may contribute to parasite elimination during Plasmodium development in the liver.

SUBMITTER: Gomes-Santos CS

PROVIDER: S-EPMC3253080 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.

Gomes-Santos Carina S S CS Itoe Maurice A MA Afonso Cristina C Henriques Ricardo R Gardner Rui R Sepúlveda Nuno N Simões Pedro D PD Raquel Helena H Almeida António Paulo AP Moita Luis F LF Frischknecht Friedrich F Mota Maria M MM

PloS one 20120106 1

Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown. Here we show that highly dynamic hepatocyte actin reorganization events occur around developing Plasmodium berghei parasites inside human hepatoma cells. Actin reorganizat ...[more]

PMID: 22238609

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