Ontology highlight
ABSTRACT:
SUBMITTER: Ives A
PROVIDER: S-EPMC3253482 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Ives Annette A Ronet Catherine C Prevel Florence F Ruzzante Giulia G Fuertes-Marraco Silvia S Schutz Frederic F Zangger Haroun H Revaz-Breton Melanie M Lye Lon-Fye LF Hickerson Suzanne M SM Beverley Stephen M SM Acha-Orbea Hans H Launois Pascal P Fasel Nicolas N Masina Slavica S
Science (New York, N.Y.) 20110201 6018
Mucocutaneous leishmaniasis is caused by infections with intracellular parasites of the Leishmania Viannia subgenus, including Leishmania guyanensis. The pathology develops after parasite dissemination to nasopharyngeal tissues, where destructive metastatic lesions form with chronic inflammation. Currently, the mechanisms involved in lesion development are poorly understood. Here we show that metastasizing parasites have a high Leishmania RNA virus-1 (LRV1) burden that is recognized by the host ...[more]