Ontology highlight
ABSTRACT:
SUBMITTER: Rossi SL
PROVIDER: S-EPMC3253985 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Virology 20111216 1
Four serotypes of dengue virus (DENV 1-4) currently circulate between humans and domestic/peridomestic Aedes mosquitoes, resulting in 100 million infections per year. All four serotypes emerged, independently, from sylvatic progenitors transmitted among non-human primates by arboreal Aedes mosquitoes. This study investigated the genetic and phenotypic changes associated with emergence of human DENV-4 from its sylvatic ancestors. Analysis of complete genomes of 3 sylvatic and 4 human strains reve ...[more]