Ontology highlight
ABSTRACT:
SUBMITTER: Gallichotte EN
PROVIDER: S-EPMC6226424 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Cell reports 20181001 5
There are four distinct DENV serotypes, and within DENV4, there are five distinct genotypes. The impact of genotypic diversity is not known, nor is it clear whether infection with one DENV4 genotype results in protective immunity against the other genotypes. To measure the impact of DENV4 genetic diversity, we generated an isogenic panel of viruses containing the envelope protein from the different genotypes. We characterized many properties of these viruses and find that a small number of amino ...[more]