Soluble A? oligomer production and toxicity.
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ABSTRACT:
SUBMITTER: Larson ME
PROVIDER: S-EPMC3254782 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Soluble Aβ oligomer production and toxicity.
Larson Megan E ME Lesné Sylvain E SE
Journal of neurochemistry 20111128
For nearly 100 years following the first description of this neurological disorder by Dr Alois Alzheimer, amyloid plaques and neurofibrillary tangles have been hypothesized to cause neuronal loss. With evidence that the extent of insoluble, deposited amyloid poorly correlated with cognitive impairment, research efforts focused on soluble forms of Aβ, also referred as Aβ oligomers. Following a decade of studies, soluble oligomeric forms of Aβ are now believed to induce the deleterious cascade(s) ...[more]
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