Ontology highlight
ABSTRACT:
SUBMITTER: Takayama K
PROVIDER: S-EPMC3255576 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Takayama Kazuo K Inamura Mitsuru M Kawabata Kenji K Katayama Kazufumi K Higuchi Maiko M Tashiro Katsuhisa K Nonaka Aki A Sakurai Fuminori F Hayakawa Takao T Furue Miho Kusuda MK Mizuguchi Hiroyuki H
Molecular therapy : the journal of the American Society of Gene Therapy 20111108 1
Hepatocyte-like cells from human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are expected to be a useful source of cells drug discovery. Although we recently reported that hepatic commitment is promoted by transduction of SOX17 and HEX into human ESC- and iPSC-derived cells, these hepatocyte-like cells were not sufficiently mature for drug screening. To promote hepatic maturation, we utilized transduction of the hepatocyte nuclear factor 4α (HNF4α) gene, which is known ...[more]