Ontology highlight
ABSTRACT:
SUBMITTER: Su M
PROVIDER: S-EPMC4456731 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Su Min M Hu Rong R Jin Jingjun J Yan Yuan Y Song Yinhong Y Sullivan Ryan R Lai Laijun L
Scientific reports 20150605
Thymic epithelial cells (TECs) are the major components of the thymic microenvironment for T cell development. TECs are derived from thymic epithelial progenitors (TEPs). It has been reported that human ESCs (hESCs) can be directed to differentiate into TEPs in vitro. However, the efficiency for the differentiation is low. Furthermore, transplantation of hESC-TEPs in mice only resulted in a very low level of human T cell development from co-transplanted human hematopoietic precursors. We show he ...[more]