Ontology highlight
ABSTRACT:
SUBMITTER: Allison AB
PROVIDER: S-EPMC3255849 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Allison Andrew B AB Harbison Carole E CE Pagan Israel I Stucker Karla M KM Kaelber Jason T JT Brown Justin D JD Ruder Mark G MG Keel M Kevin MK Dubovi Edward J EJ Holmes Edward C EC Parrish Colin R CR
Journal of virology 20111109 2
Understanding the mechanisms of cross-species virus transmission is critical to anticipating emerging infectious diseases. Canine parvovirus type 2 (CPV-2) emerged as a variant of a feline parvovirus when it acquired mutations that allowed binding to the canine transferrin receptor type 1 (TfR). However, CPV-2 was soon replaced by a variant virus (CPV-2a) that differed in antigenicity and receptor binding. Here we show that the emergence of CPV involved an additional host range variant virus tha ...[more]