Ontology highlight
ABSTRACT:
SUBMITTER: Acloque H
PROVIDER: S-EPMC3256632 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Acloque Hervé H Ocaña Oscar H OH Matheu Ander A Rizzoti Karine K Wise Clare C Lovell-Badge Robin R Nieto M Angela MA
Developmental cell 20110901 3
In developing amniote embryos, the first epithelial-to-mesenchymal transition (EMT) occurs at gastrulation, when a subset of epiblast cells moves to the primitive streak and undergoes EMT to internalize and generate the mesoderm and the endoderm. We show that in the chick embryo this decision to internalize is mediated by reciprocal transcriptional repression of Snail2 and Sox3 factors. We also show that the relationship between Sox3 and Snail is conserved in the mouse embryo and in human cancer ...[more]