Ontology highlight
ABSTRACT:
SUBMITTER: Chang WC
PROVIDER: S-EPMC3258251 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Chang Wei-Chiao WC Lee Chih-Hung CH Hirota Tomomitsu T Wang Li-Fang LF Doi Satoru S Miyatake Akihiko A Enomoto Tadao T Tomita Kaori K Sakashita Masafumi M Yamada Takechiyo T Fujieda Shigeharu S Ebe Koji K Saeki Hidehisa H Takeuchi Satoshi S Furue Masutaka M Chen Wei-Chiao WC Chiu Yi-Ching YC Chang Wei Pin WP Hong Chien-Hui CH Hsi Edward E Juo Suh-Hang Hank SH Yu Hsin-Su HS Nakamura Yusuke Y Tamari Mayumi M
PloS one 20120113 1
Atopic dermatitis is a chronic inflammatory skin disease. Multiple genetic and environmental factors are thought to be responsible for susceptibility to AD. In this study, we collected 2,478 DNA samples including 209 AD patients and 729 control subjects from Taiwanese population and 513 AD patients and 1027 control subject from Japanese population for sequencing and genotyping ORAI1. A total of 14 genetic variants including 3 novel single-nucleotide polymorphisms (SNPs) in the ORAI1 gene were id ...[more]