Ontology highlight
ABSTRACT:
SUBMITTER: Sobetzko P
PROVIDER: S-EPMC3258614 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Sobetzko Patrick P Travers Andrew A Muskhelishvili Georgi G
Proceedings of the National Academy of Sciences of the United States of America 20111219 2
In Escherichia coli crosstalk between DNA supercoiling, nucleoid-associated proteins and major RNA polymerase σ initiation factors regulates growth phase-dependent gene transcription. We show that the highly conserved spatial ordering of relevant genes along the chromosomal replichores largely corresponds both to their temporal expression patterns during growth and to an inferred gradient of DNA superhelical density from the origin to the terminus. Genes implicated in similar functions are relat ...[more]