Ontology highlight
ABSTRACT:
SUBMITTER: Mulligan KA
PROVIDER: S-EPMC3258625 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Mulligan Kimberly A KA Fuerer Christophe C Ching Wendy W Fish Matt M Willert Karl K Nusse Roeland R
Proceedings of the National Academy of Sciences of the United States of America 20111227 2
Lipid-modified Wnt/Wingless (Wg) proteins can signal to their target cells in a short- or long-range manner. How these hydrophobic proteins travel through the extracellular environment remains an outstanding question. Here, we report on a Wg binding protein, Secreted Wg-interacting molecule (Swim), that facilitates Wg diffusion through the extracellular matrix. Swim, a putative member of the Lipocalin family of extracellular transport proteins, binds to Wg with nanomolar affinity in a lipid-depe ...[more]